Heparin-Binding Protein Measurement Improves the Prediction of Severe Infection With Organ Dysfunction in the Emergency Department.

Summary, in English

Early identification of patients with infection and at risk of developing severe disease with organ dysfunction remains a difficult challenge. We aimed to evaluate and validate the heparin-binding protein, a neutrophil-derived mediator of vascular leakage, as a prognostic biomarker for risk of progression to severe sepsis with circulatory failure in a multicenter setting.

• Author: Adam Linder; Ryan Arnold; John H Boyd; Marko Zindovic; Igor Zindovic; Anna Lange; Magnus Paulsson; Patrik Nyberg; James A Russell; David Pritchard; Bertil Christensson; Per Åkesson
• Department/s: Infection Medicine (BMC); Translational Sepsis research; Thoracic Surgery; Clinical Microbiology, Malmö
• Publishing year: 2015
• Language: English
• Pages: 2378-2386
• Publication/Series: Critical Care Medicine
• Volume: 43
• Issue: 11
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26468696?dopt=Abstract; http://dx.doi.org/10.1097/CCM.0000000000001265
• Document type: Journal article
• Publisher: Lippincott Williams & Wilkins
• Topic: Anesthesiology and Intensive Care
• Status: Published
• Research group: Translational Sepsis research; Clinical Microbiology, Malmö
• ISBN/ISSN/Other: ISSN: 1530-0293