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Neuroblastoma as an experimental model for neuronal differentiation and hypoxia-induced tumor cell dedifferentiation.

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Author

Summary, in English

Neuroblastoma is a childhood tumor derived from precursor or immature cells of the sympathetic nervous system. Neuroblastomas show a tremendous clinical heterogeneity, encompassing truly benign as well as extremely aggressive forms. In vivo as well as in vitro data have shown that the degree of sympathetic neuronal tumor cell differentiation influences patient outcome. Unraveling mechanisms governing neuroblastoma cell differentiation is therefore a central issue in the neuroblastoma research field. In this communication, we discuss some of the in vitro models frequently used to study human neuroblastoma cell differentiation. We also review recent data demonstrating that oxygen shortage, hypoxia, shifts neuroblastoma cells toward an immature, stem cell-like phenotype and discuss the potential clinical impact of hypoxia on neuroblastoma behavior.

Publishing year

2007

Language

English

Pages

248-256

Publication/Series

Seminars in Cancer Biology

Volume

17

Issue

3

Document type

Journal article review

Publisher

Academic Press

Topic

  • Cancer and Oncology

Keywords

  • neuroblastoma
  • hypoxia
  • sympathetic nervous
  • neuronal differentiation
  • system

Status

Published

ISBN/ISSN/Other

  • ISSN: 1096-3650