Pharmacokinetic studies on 5-aminolevulinic acid-induced protoporphyrin IX accumulation in tumours and normal tissues

Summary, in English

Laser-induced fluorescence (LIF) for in vivo point monitoring and fluorescence microscopy incorporating a CCD camera were used to study the fluorescence distribution of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) in tumours. Fluorescence in a chemically induced adenocarcinoma in the liver of rats and in an aggressive basal cell carcinoma in a patient were studied after intravenous injection of ALA at a dose of 30 mg/kg body weight. The LIF technique demonstrated slightly more ALA-induced PpIX fluorescence in the tumour than in the surrounding normal liver and abdominal muscle of rats. The visible parts of the human basal cell carcinoma exhibited strong ALA-induced fluorescence, while this fluorescence was much weaker in the necrotic areas of the tumour and in the surrounding normal skin. (C) 1997 Elsevier Science ireland Ltd.

• Author: H Heyerdahl; I Wang; D. L Liu; R Berg; Stefan Andersson-Engels; Q Peng; J Moan; Sune Svanberg; Katarina Svanberg
• Department/s: Atomic Physics
• Publishing year: 1997
• Language: English
• Pages: 225-231
• Publication/Series: Cancer Letters
• Volume: 112
• Issue: 2
• Full text: - 1 MB; Download statistics
• Links: http://dx.doi.org/10.1016/S0304-3835(96)04576-4
• Document type: Journal article
• Publisher: Elsevier
• Topic: Cancer and Oncology
• Status: Published
• ISBN/ISSN/Other: ISSN: 1872-7980