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The clinicopathological and gene expression patterns associated with ulceration of primary melanoma

På svenska

Author

  • Rosalyn Jewell
  • Faye Elliott
  • Jonathan Laye
  • Jeremie Nsengimana
  • John Davies
  • Christy Walker
  • Caroline Conway
  • Angana Mitra
  • Mark Harland
  • Martin G. Cook
  • Andy Boon
  • Sarah Storr
  • Sabreena Safuan
  • Stewart G. Martin
  • Karin Jirström
  • Håkan Olsson
  • Christian Ingvar
  • Martin Lauss
  • Tim Bishop
  • Göran B Jönsson
  • Julia Newton-Bishop
Show all

Summary, in English

Ulceration of primary melanomas is associated with poor prognosis yet is reported to predict benefit from adjuvant interferon. To better understand the biological processes involved, clinicopathological factors associated with ulceration were determined in 1804 patients. From this cohort, 348 primary tumor blocks were sampled to generate gene expression data using a 502-gene cancer panel and 195 blocks were used for immunohistochemistry to detect macrophage infiltration and vessel density. Gene expression results were validated using a whole genome array in two independent sample sets. Ulceration of primary melanomas was associated with more proliferative tumors, tumor vessel invasion, and increased microvessel density. Infiltration of tumors with greater number of macrophages and gene expression pathways associated with wound healing and up-regulation of pro-inflammatory cytokines suggests that ulceration is associated with tumor-related inflammation. The relative benefit from interferon reported in patients with ulcerated tumors may reflect modification of signaling pathways involved in inflammation.

Department/s

Publishing year

2015

Language

English

Pages

94-104

Publication/Series

Pigment Cell & Melanoma Research

Volume

28

Issue

1

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Cancer and Oncology

Keywords

  • melanoma
  • primary
  • ulceration
  • gene expression
  • clinicopathological
  • immunohistochemistry

Status

Published

ISBN/ISSN/Other

  • ISSN: 1755-148X