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Biologically active secondary metabolites from the ascomycete A111-95 - 1. Production, isolation and biological activities

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Author

Summary, in English

Eight secondary metabolites were isolated from submerged cultures of the ascomycete A111-95 during a search for new nematicidal metabolites. (-)-Galiellalactone (7) and compound 2 are metabolites previously obtained from cultures of Galiella rufa while the compounds 1, 3, 4, 5, 6 and 8 (3 and 4 were obtained as an unseparable mixture), were isolated as natural products for the first time. Compound 2, pregaliellalactone (5) and the mixture of 3 and 4 showed nematicidal activities towards Caenorhabditis elegans and Meloidogyne incognita. All compounds showed moderate or weak cytotoxic activities.

Publishing year

2002

Language

English

Pages

36-40

Publication/Series

Journal of Antibiotics

Volume

55

Issue

1

Document type

Journal article

Publisher

Japan Antibiotics Research Association

Topic

  • Organic Chemistry

Status

Published

ISBN/ISSN/Other

  • ISSN: 0021-8820