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Loss of size-selectivity at histamine-induced exudation of plasma proteins in atopic nasal airways.

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Author

Summary, in English

Plasma proteins occur in the airway lumen in inflammatory airway diseases. This study tests the hypothesis that airway microvascular-epithelial exudation of plasma proteins, as induced by a non-injurious inflammatory mediator, is characterized by loss of size-selectivity. Using a nasal pool-device, the nasal mucosa of 10 allergic individuals, without current disease, was sequentially exposed to saline and histamine (40 and 400 microg ml(-1)). Nasal lavage fluid and blood-levels of albumin (69 kD) and alpha2-macroglobulin (720 kD) were determined. Histamine produced concentration-dependent exudation of albumin and alpha2-macroglobulin. The albumin/alpha2-macroglobulin concentration ratio of the saline lavage fluid (baseline) was 40+/-19. However, at the histamine challenges the ratios were 25+/-3 and 22+/-2, respectively, which did not differ from that of circulating plasma (22+/-2). We conclude that there is minor and size-selective luminal entry of plasma proteins at baseline. However, at concentration-dependent exudative responses to histamine, plasma proteins enter the airway lumen without being sieved. These data indicate that inflammatory stimulus-induced extravasation, lamina propria distribution and paracellular epithelial passage of plasma occur with minimal size-selectivity. Inferentially, the full immunological capacity of plasma proteins may readily be made available at the surface of human intact airway mucosa.

Publishing year

2002

Language

English

Pages

28-31

Publication/Series

Clinical Physiology and Functional Imaging

Volume

22

Issue

1

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Physiology

Keywords

  • Dose-Response Relationship
  • Drug
  • Histamine : administration & dosage
  • Histamine : pharmacology
  • Human
  • Hypersensitivity : metabolism
  • Nasal Lavage Fluid : chemistry
  • Nasal Mucosa : drug effects
  • alpha-Macroglobulins : metabolism
  • Non-U.S. Gov't
  • Support
  • Serum Albumin : metabolism
  • Nasal Mucosa : metabolism
  • Permeability
  • Blood Proteins : metabolism
  • Adult

Status

Published

Research group

  • Airway Inflammation and Immunology

ISBN/ISSN/Other

  • ISSN: 1475-0961