Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

Summary, in English

Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10). This finding suggests a novel pathway that may contribute to the development of type 2 diabetes.

• Author: Y Horikawa; N Oda; N J Cox; X Li; Marju Orho-Melander; M Hara; Y Hinokio; T H Lindner; H Mashima; P E Schwarz; L del Bosque-Plata; Y Horikawa; Y Oda; I Yoshiuchi; S Colilla; K S Polonsky; S Wei; P Concannon; N Iwasaki; J Schulze; Leslie J. Baier; Clifton Bogardus; Leif Groop; Eric Boerwinkle; Craig L. Hanis; Graeme I. Bell
• Department/s: Translational Muscle Research
• Publishing year: 2000
• Language: English
• Pages: 163-175
• Publication/Series: Nature Genetics
• Volume: 26
• Issue: 2
• Links: http://dx.doi.org/10.1038/79876
• Document type: Journal article
• Publisher: Nature Publishing Group
• Topic: Endocrinology and Diabetes
• Status: Published
• Research group: Translational Muscle Research
• ISBN/ISSN/Other: ISSN: 1546-1718