Non-fibrosing sclerosing epithelioid fibrosarcoma: An unusual variant.

Summary, in English

Sclerosing epithelioid fibrosarcoma (SEF), first described in 1995, is a rare aggressive sarcoma morphologically defined by "epithelioid fibroblasts arranged in distinct cords and nests in a densely sclerotic, hyalinised stroma". SEF can mimic metastatic carcinoma within desmoplastic stroma, lymphoma and other mesenchymal neoplasms such as myoepithelioma, making it difficult to diagnose. In a subset of cases there is morphological overlap between SEF and low grade fibromyxoid sarcoma (LGFMS), a low grade fibroblastic sarcoma. Progression of LGFMS to SEF in single cases is well documented. Recent studies detected EWSR1-CREB3L1 fusion transcripts in a high proportion of SEF. This article is protected by copyright. All rights reserved.

• Author: Florian Puls; Linda Magnusson; Angela Niblett; Hassan Douis; David Peake; Philippe Taniere; Lars-Gunnar Kindblom; Fredrik Mertens
• Department/s: Division of Clinical Genetics; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publishing year: 2015-07-25
• Language: English
• Publication/Series: Histopathology
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26212576?dopt=Abstract; http://dx.doi.org/10.1111/his.12791
• Document type: Journal article (letter)
• Publisher: Wiley-Blackwell
• Topic: Cancer and Oncology
• Status: Published
• ISBN/ISSN/Other: ISSN: 0309-0167