PDGFB regulates the development of the labyrinthine layer of the mouse fetal placenta.
Author
Summary, in English
PDGFB is a growth factor which is vital for the completion of normal prenatal development. In this study, we report the phenotypic analysis of placentas from mouse conceptuses that lack a functional PDGFB or PDGFRbeta gene. Placentas of both types of mutant exhibit changes in the labyrinthine layer, including dilated embryonic blood vessels and reduced numbers of both pericytes and trophoblasts. These changes are seen from embryonic day (E) 13.5, which coincides with the upregulation of PDGFB mRNA levels in normal placentas. By E17, modifications in shape, size, and number of the fetal blood vessels in the mutant placentas cause an abnormal ratio of the surface areas between the fetal and the maternal blood vessels in the labyrinthine layer. Our data suggest that PDGFB acts locally to contribute to the development of the labyrinthine layer of the fetal placenta and the formation of a proper nutrient-waste exchange system during fetal development. We point out that the roles of PDGFB/Rbeta signaling in the placenta may be analogous to those in the developing kidney, by controlling pericytes in the labyrinthine layer and mesangial cells in the kidney.
Publishing year
1999
Language
English
Pages
124-136
Publication/Series
Developmental Biology
Volume
212
Issue
1
Links
Document type
Journal article
Publisher
Elsevier
Topic
- Medical Genetics
Keywords
- Proto-Oncogene Proteins
- Pregnancy
- Platelet-Derived Growth Factor
- Placenta
- Pericytes
- Biological
- Models
- Knockout
- Mice
- Maternal-Fetal Exchange
- Kidney
- Female
- Animals
- Capillaries
- Proto-Oncogene Proteins c-sis
- Receptors
- Time Factors
- Trophoblasts
Status
Published
ISBN/ISSN/Other
- ISSN: 1095-564X