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Low serum levels of short-chain fatty acids after lactulose ingestion may indicate impaired colonic fermentation in patients with irritable bowel syndrome.

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Author

  • Ragnhild Undseth
  • Greta Jakobsdottir
  • Margareta Nyman
  • Arnold Berstad
  • Jørgen Valeur

Summary, in English

Ingestion of low-digestible carbohydrates triggers symptoms in patients with irritable bowel syndrome (IBS). These carbohydrates become substrates for microbial fermentation in the colon, yielding short-chain fatty acids (SCFAs) that are readily absorbed. Aiming to compare colonic fermentation in patients with IBS and healthy controls, we analyzed the concentrations of SCFA in serum at fasting and 90 minutes following ingestion of an unabsorbable, but fermentable carbohydrate, lactulose.

Department/s

  • Food for Health Science Centre, Kemicentrum

Publishing year

2015

Language

English

Pages

303-308

Publication/Series

Clinical and Experimental Gastroenterology

Volume

8

Document type

Journal article

Publisher

Dove Medical Press Ltd.

Topic

  • Nutrition and Dietetics

Status

Published

ISBN/ISSN/Other

  • ISSN: 1178-7023