Impact of transcription factor 7-like 2 (TCF7L2) on pancreatic islet function and morphology in mice and men.

Summary, in English

Common genetic variations in the gene encoding transcription factor 7-like 2 (TCF7L2) reveal the strongest association with type 2-diabetes known to date. These lead to impaired insulin production and output, but the mechanisms of disease remain incompletely known. In this issue of Diabetologia, two publications provide new insights into TCF7L2-dependent diabetes.

• Author: Erik Renström
• Department/s: Diabetes - Islet Patophysiology; EXODIAB: Excellence of Diabetes Research in Sweden
• Publishing year: 2012
• Language: English
• Pages: 2559-2561
• Publication/Series: Diabetologia
• Volume: 55
• Issue: 10
• Full text: - 109 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/22864463?dopt=Abstract; http://dx.doi.org/10.1007/s00125-012-2659-1
• Document type: Journal article
• Publisher: Springer
• Topic: Endocrinology and Diabetes
• Status: Published
• Research group: Diabetes - Islet Patophysiology
• ISBN/ISSN/Other: ISSN: 1432-0428