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A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris).

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Author

  • G Appendino
  • C Della Porta
  • G Conseil
  • Olov Sterner
  • E Mercalli
  • C Dumontet
  • A Di Pietro

Summary, in English

The macrocyclic lathyrane polyester Euphorbia factor L10 (1a) has been obtained from the seeds of the caper spurge (E. lathyris). The interaction of L10 (1a) and its acetyl derivative (1b) with P-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. The results established lathyrane diterpenoids as a novel chemotype for P-glycoprotein inhibitors.

Publishing year

2003

Language

English

Pages

140-142

Publication/Series

Journal of Natural Products

Volume

66

Issue

1

Document type

Journal article

Publisher

The American Chemical Society (ACS)

Topic

  • Organic Chemistry

Status

Published

ISBN/ISSN/Other

  • ISSN: 0163-3864