Human papilloma virus in skin, mouth and uterine cervix in female renal transplant recipients with or without a history of cutaneous squamous cell carcinoma

Summary, in English

Some human papilloma viruses are thought to be associated with skin cancer. In this pilot study, 21 female renal transplant carriers, 10 with a history of skin squamous cell carcinoma and 11 without, together with 9 age-matched healthy women were investigated for human papilloma virus DNA in sun-exposed (forehead) and less sun-exposed (buttock) skin, mouth and uterine cervix. Paraffin-embedded tumours from 9 of the patients with a history of squamous cell carcinoma were analysed. Healthy skin from both the healthy and the immunosuppressed individuals harboured a wide variety of papilloma viruses. In the healthy individuals, samples from less sun-exposed skin showed a lower prevalence of human papilloma virus DNA than corresponding samples from the immunosuppressed patients (4/9 and 7/9, respectively). Among the immunosuppressed patients, human papillomavirus DNA was found as frequently in buttock samples (17/21) as in forehead samples (17/20). There was no increased prevalence of human papillomavirus in the cervix or mouth samples from the immunosuppressed patients.

• Author: Peter Nordin; Bengt-Göran Hansson; Carita Hansson; Ingemar Blohme; Olle Larko; Kristin Andersson
• Department/s: Clinical Microbiology, Malmö; Epidemiology
• Publishing year: 2007
• Language: English
• Pages: 219-222
• Publication/Series: Acta Dermato-Venereologica
• Volume: 87
• Issue: 3
• Links: http://dx.doi.org/10.2340/00015555-0235
• Document type: Journal article
• Publisher: Medical Journals Limited
• Topic: Dermatology and Venereal Diseases
• Keywords: polymerase chain; human papilloma virus; kidney transplant patients; squamous cell carcinoma; reaction
• Status: Published
• Research group: Clinical Microbiology, Malmö; Epidemiology
• ISBN/ISSN/Other: ISSN: 1651-2057