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Weak telomerase activity in malignant cells in metastatic serous effusions - Correlation to short survival time

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Author

Summary, in English

Objective The purpose of this study was to evaluate whether the intensity of telomerase activity measured on the cellular level in effusions correllates to survival time in cases of metastatic spread to the serous cavities. Study Design Telomere repeat amplification protocol (TRAP) in situ was applied to 46 effusions containing metastatic cancer cells. Results Weak telomerase activity in tumor cells was seen in 7 cases, and moderate or strong activity in 39 cases. The intensity of the enzyme activity correlated significantly to survival (Kaplan-Meier survival analysis), the median survival time being 18 days for patients with weakly positive tumors and 100 days for patients with moderately or strongly positive tumors (Kruskal-Wallis test, p=0.021). Conclusion The strong relationship between telomerase activity in tumor cells in effusions and survival time has never been described before. Determination of telomerase activity on the cellular level provides a way to identify a subgroup of patients with a high probability of short survival.

Department/s

Publishing year

2007

Language

English

Pages

412-416

Publication/Series

Acta Cytologica

Volume

51

Issue

3

Document type

Journal article

Publisher

Karger

Topic

  • Cancer and Oncology
  • Cell and Molecular Biology

Keywords

  • telomere repeat amplification
  • telomerase
  • carcinoma
  • effusions
  • protocol
  • survival

Status

Published

Research group

  • Pathology, Malmö

ISBN/ISSN/Other

  • ISSN: 0001-5547