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Functional in vitro characterisation of the androgen receptor GGN polymorphism.

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Author

Summary, in English

Superior androgen receptor (AR) function in subjects carrying a GGN repeat length of 23 (GGN23) has been indicated in vivo. Therefore, the activity of the AR carrying GGN23 combined with CAG22 was compared to the AR with GGN10, 24 and 27, respectively, in the presence of 0.1-100 nM testosterone or DHT. At 100 nM DHT, GGN24 showed 35% lower transactivating activity (95% [CI]: 20-50%) than GGN23. GGN10 and GGN27 also showed significantly less AR activity than GGN23 (mean differences [95% CI]: 54% [40-68%] and 58% [39-78%], respectively). The same trend was also observed at lower DHT concentrations. In response to R 188 1, GGN23 activity was significantly higher than for other lengths. ARs with other glutamine numbers than 23 have lower transactivating capacity in response to both testosterone and DHT. Congenital malformations and other signs of hypoandrogenism in subjects with AR gene GGN lengths other than 23 could, hence, be related to a lower AR activity.

Department/s

Publishing year

2007

Language

English

Pages

184-187

Publication/Series

Molecular and Cellular Endocrinology

Volume

264

Issue

1-2

Document type

Journal article

Publisher

Elsevier

Topic

  • Endocrinology and Diabetes

Keywords

  • polymorphism
  • androgen receptor
  • transcription

Status

Published

Research group

  • Reproductive medicine, Malmö
  • Urological research, Malmö

ISBN/ISSN/Other

  • ISSN: 1872-8057