Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors
Author
Summary, in English
p16(INK4a), p15(INK4b), p18(INK4c) and p19(INK4d) comprise a family of cyclin-dependent kinase inhibitors and tumor suppressors. We report that the INK4 proteins share the ability to arrest cells in G1, and interact with CDK4 or CDK6 with similar avidity. In contrast, only p18 and particularly p19 are phosphorylated in vivo, and each of the human INK4 proteins shows unique expression patterns dependent on cell and tissue type, and differentiation stage. Thus, the INK4 proteins harbor redundant as well as non-overlapping properties, suggesting distinct regulatory modes, and diverse roles for the individual INK4 family members in cell cycle control, cellular differentiation, and multistep oncogenesis.
Publishing year
2000
Language
English
Pages
161-166
Publication/Series
FEBS Letters
Volume
470
Issue
2
Links
Document type
Journal article
Publisher
Wiley-Blackwell
Topic
- Medicinal Chemistry
Status
Published
ISBN/ISSN/Other
- ISSN: 1873-3468