TCF7L2 type 2 diabetes risk variant, lifestyle factors, and incidence of prostate cancer.

Summary, in English

Variation in transcription factor 7-like 2 (TCF7L2), the strongest genetic risk factor for type 2 diabetes (T2D), may play a role in prostate cancer (PCa) depending on lifestyle factors. The aims of this study were to determine if TCF7L2 rs7903146 is associated with risk of PCa and if the association is modified by lifestyle factors independently of T2D status.

• Author: Isabel Drake; Peter Wallström; George Hindy; Ulrika Ericson; Bo Gullberg; Anders Bjartell; Emily Sonestedt; Marju Orho-Melander; Elisabet Wirfält
• Department/s: EXODIAB: Excellence of Diabetes Research in Sweden; Nutrition Epidemiology; Diabetes - Cardiovascular Disease; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation; Urological cancer, Malmö; EpiHealth: Epidemiology for Health
• Publishing year: 2014
• Language: English
• Pages: 1161-1170
• Publication/Series: The Prostate
• Volume: 74
• Issue: 12
• Links: http://www.ncbi.nlm.nih.gov/pubmed/24961829?dopt=Abstract; http://dx.doi.org/10.1002/pros.22832
• Document type: Journal article
• Publisher: John Wiley & Sons Inc.
• Topic: Obstetrics, Gynecology and Reproductive Medicine
• Status: Published
• Research group: Nutrition Epidemiology; Diabetes - Cardiovascular Disease; Urological cancer, Malmö
• ISBN/ISSN/Other: ISSN: 0270-4137