Changes in the Levels of Neurospecific Proteins and in Behavioral Phenomena in Rats with Hepatic Encephalopathy
Author
Summary, in English
We showed that, under conditions of experimental chronic hepatitis, excessive increases in the levels of a Ca-binding protein, S-100b, and a neuronal cell adhesion molecule, NCAM, occur in all parts of the brain of Wistar rats. This is accompanied by suppression of locomotor and orientational/research activity of the animals and increase in their stress sensitivity. Treatment by a ketoglutarate and cytoflavin in chronic hepatitis provides a clear neuroprotective effect.
Department/s
Publishing year
2011
Language
English
Pages
205-208
Publication/Series
Neurophysiology
Volume
43
Issue
3
Document type
Journal article
Publisher
Springer
Topic
- Zoology
Keywords
- hepatic encephalopathy
- S-100b
- NCAM
- behavior
Status
Published
ISBN/ISSN/Other
- ISSN: 0090-2977