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Acute contractile effects of epidermal growth factor on bladder smooth muscles. An in vivo and in vitro study in rats

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Author

Summary, in English

Chronic treatment with epidermal growth factor (EGF) stimulates growth of all wall layers of the urinary tract in pigs and rats. Herein, we investigated the acute effects of EGF on detrusor smooth muscle activity. For in vivo examination, awake rats received EGF (75 micrograms/kg) intravenously and detrusor smooth muscle activity was monitored cystometrically. The EGF bolus caused no alteration in diuresis but a doubling of the micturition frequency, a 25% increase in micturition pressures, and increased irregular baseline contractile activity. For in vitro examination detrusor smooth muscle strips were exposed to EGF (1 microgram/ml). EGF caused contraction and increase in the spontaneous activity. In conclusion, EGF increases rat detrusor smooth muscle contractile activity in vivo and in vitro. The finding suggests that a direct effect of EGF on bladder smooth muscles is part of the genesis to the growth of the detrusor smooth muscle observed after chronic EGF treatment.

Publishing year

1997

Language

English

Pages

231-235

Publication/Series

Scandinavian Journal of Urology and Nephrology

Volume

31

Issue

3

Document type

Journal article

Publisher

Taylor & Francis

Topic

  • Urology and Nephrology
  • Physiology
  • Neurosciences

Keywords

  • Bladder
  • muscle contraction
  • smooth muscle

Status

Published

Research group

  • Brain Repair and Imaging in Neural Systems (BRAINS)
  • Vascular Physiology
  • Urology

ISBN/ISSN/Other

  • ISSN: 0036-5599