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Prediction of disease-related mutations affecting protein localization.

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Author

Summary, in English

Eukaryotic cells contain numerous compartments, which have different protein constituents. Proteins are typically directed to compartments by short peptide sequences that act as targeting signals. Translocation to the proper compartment allows a protein to form the necessary interactions with its partners and take part in biological networks such as signalling and metabolic pathways. If a protein is not transported to the correct intracellular compartment either the reaction performed or information carried by the protein does not reach the proper site, causing either inactivation of central reactions or misregulation of signalling cascades, or the mislocalized active protein has harmful effects by acting in the wrong place.

Publishing year

2009

Language

English

Publication/Series

BMC Genomics

Volume

10

Document type

Journal article

Publisher

BioMed Central (BMC)

Topic

  • Genetics

Keywords

  • Computational Biology: methods
  • Genetic Predisposition to Disease: genetics
  • Intracellular Space: metabolism
  • Proteins: genetics
  • Proteins: metabolism

Status

Published

ISBN/ISSN/Other

  • ISSN: 1471-2164