In Vitro Activity of Lipopeptides Pal-Lys-Lys-NH2 and Pal-Lys-Lys Alone and in Combination with Antimicrobial Agents against Multiresistant Gram-positive Cocci.

Summary, in English

The in vitro activities of the lipopeptides pahnitoyl (Pal)-Lys-Lys-NH2 and Pal-Lys-Lys against gram-positive cocci were investigated. Enterococci and streptococci demonstrated higher susceptibilities than staphylococci and Rhodococcus equi. A positive interaction was shown when the lipopeptides were combined with beta-lactams and vancomycin. These results suggest that lipopeptides are promising candidates for antimicrobial therapy for infections caused by gram-positive organisms.

• Author: Wojciech Kamysz; Carmela Silvestri; Oscar Cirioni; Andrea Giacometti; Alberto Licci; Agnese Della Vittoria; Marcin Okroj; Giorgio Scalise
• Department/s: Clinical Chemistry, Malmö
• Publishing year: 2007
• Language: English
• Pages: 354-358
• Publication/Series: Antimicrobial Agents and Chemotherapy
• Volume: 51
• Issue: 1
• Links: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17060532&dopt=Abstract; http://dx.doi.org/10.1128/AAC.00344-06
• Document type: Journal article
• Publisher: American Society for Microbiology
• Topic: Medicinal Chemistry
• Status: Published
• Research group: Clinical Chemistry, Malmö
• ISBN/ISSN/Other: ISSN: 1098-6596