Antileishmanial metabolites from Lantana balansae
Author
Summary, in English
Eleven compounds, 12-oxo-phytodienoic acid (1), persicogenin (2), eriodictyol 3ʹ4ʹ,7-trimethyl ether (3), phytol (4), spathulenol (5), 4-hydroxycinnamic acid (6), onopordin (7), 5,8,4ʹ-trihydroxy-7,3ʹ-dimethoxyflavone (8), quercetin (9), jaceosidin (10), and 8-hydroxyluteolin (11), were isolated from an ethanol extract of Lantana balansae Briq., Verbenaceae, that was found to possess antileishmanial activ-ity. The structures of the compounds were determined by NMR spectroscopy and HR mass spectrometry, and 1, 2, 3, 7, 8 and 9 were investigated for antiprotozoal activity toward promastigotes of Leishmania amazonensis and Leishmania braziliensis. Compound 1 was shown to be the most potent, with the IC50 values 2.0µM toward L. amazonensis and 0.68µM toward L. braziliensis, although less potent than the positive control Amphotericin B. All compounds have been reported previously, but this is the first report of the isolation of a cyclopentenone fatty acid (1) and flavanones (2 and 3) from a Lantana species.
Department/s
Publishing year
2016-01-01
Language
English
Pages
180-183
Publication/Series
Brazilian Journal of Pharmacognosy
Volume
26
Issue
2
Document type
Journal article
Publisher
Sociedade Brasileira de Farmacognosia
Topic
- Pharmaceutical Sciences
Keywords
- 12-oxo-phytodienoic acid
- Flavonoids
- L. braziliensis
- Lantana balansae
- Leishmania amazonensis
Status
Published
ISBN/ISSN/Other
- ISSN: 0102-695X