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Poly(ethylene glycol)-containing supports for solid-phase synthesis of peptides and combinatorial organic libraries.

På svenska

Author

  • George Barany
  • Fernando Albericio
  • Steven Kates
  • Maria Kempe

Editor

  • J.M. Harris
  • S. Zalipsky

Summary, in English

The choice of a polymeric support is a key factor for the success of solid-phase methods for syntheses of organic compounds and biomolecules such as peptides and oligonucleotides. Classical Merrifield solid-phase peptide synthesis, performed on low cross-linked hydrophobic polystyrene (PS) beads, sometimes suffers from sequence-dependent coupling difficulties. The concept of incorporating PEG into supports for solid-phase synthesis represents a successful approach to alleviating such problems. This chapter reviews the preparation of families of poly(ethylene glycol)-polystyrene (PEG-PS)graft as well as (highly) Cross-Linked Ethoxylate Acrylate Resin (CLEAR) supports developed in our laboratories, and demonstrates their applications to the syntheses of a wide range of targets in connection with numerous research objectives.

Publishing year

1997

Language

English

Pages

239-264

Publication/Series

Poly(ethylene glycol): Chemistry and Biological Applications, ACS Symp. Series

Volume

680

Document type

Book chapter

Publisher

The American Chemical Society (ACS)

Topic

  • Biochemistry and Molecular Biology

Status

Published

Research group

  • Nanomedicine and Biomaterials

ISBN/ISSN/Other

  • ISBN: 9780841235373