Lactobacillus plantarum 299v reduces colonisation of Clostridium difficile in critically ill patients treated with antibiotics
Author
Summary, in English
Background: The incidence of Clostridium difficile-associated disease (CDAD) in hospitalised patients is increasing. Critically ill patients are often treated with antibiotics and are at high risk of developing CDAD. Lactobacillus plantarum 299v (Lp299v) has been found to reduce recurrence of CDAD. We investigated intensive care unit (ICU) patients regarding the impact of Lp299v on C. difficile colonisation and on gut permeability and parameters of inflammation and infection in that context.
Methods: Twenty-two ICU patients were given a fermented oatmeal gruel containing Lp299v, and 22 received an equivalent product without the bacteria. Faecal samples for analyses of C. difficile and Lp299v were taken at inclusion and then twice a week during the ICU stay. Other cultures were performed on clinical indication. Infection and inflammation parameters were analysed daily. Gut permeability was assessed using a sugar probe technique.
Main Results: Colonisation with C. difficile was detected in 19% (4/21) of controls but in none of the Lp299v-treated patients (p < 0.05).
Conclusions: Enteral administration of the probiotic bacterium Lp299v to critically ill patients treated with antibiotics reduced colonisation with C. difficile.
Trial registration: Current Controlled Trials ISRCTN85655545
Methods: Twenty-two ICU patients were given a fermented oatmeal gruel containing Lp299v, and 22 received an equivalent product without the bacteria. Faecal samples for analyses of C. difficile and Lp299v were taken at inclusion and then twice a week during the ICU stay. Other cultures were performed on clinical indication. Infection and inflammation parameters were analysed daily. Gut permeability was assessed using a sugar probe technique.
Main Results: Colonisation with C. difficile was detected in 19% (4/21) of controls but in none of the Lp299v-treated patients (p < 0.05).
Conclusions: Enteral administration of the probiotic bacterium Lp299v to critically ill patients treated with antibiotics reduced colonisation with C. difficile.
Trial registration: Current Controlled Trials ISRCTN85655545
Department/s
- Anesthesiology and Intensive Care
- Infectious Diseases Research Unit
- Surgery
- Division of Food and Pharma
Publishing year
2008
Language
English
Pages
1096-1102
Publication/Series
Acta Anaesthesiologica Scandinavica
Volume
52
Issue
8
Links
Document type
Journal article
Publisher
Wiley-Blackwell
Topic
- Anesthesiology and Intensive Care
Keywords
- gut permeability
- critical illness
- Clostridium difficile
- ICU
- Lactobacillus plantarum 299v
- Clostridium difficile-associated disease
- probiotics
- CDAD
- immune function.
Status
Published
Research group
- Infectious Diseases Research Unit
- Surgery
ISBN/ISSN/Other
- ISSN: 0001-5172