Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland.

Summary, in English

This study investigated whether perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS), which exhibit reproductive toxicity in experimental animals, affect sperm sex chromosome ratio. The Y:X ratio was determined by fluorescence in situ hybridization. Serum concentrations of PFOA and PFOS were measured in 607 men from Greenland, Poland and Ukraine using liquid chromatography-tandem mass spectrometry. Data was analyzed by linear and nonlinear regression. We observed no associations between PFOA and Y:X ratio (p=0.845 in a linear model, p=0.296 in a nonlinear model). A positive nonlinear association between PFOS and Y:X ratio was observed (p=0.016), with no association in a linear model (p=0.118). Analyzing the populations separately, a negative trend between categorized PFOS exposure and Y:X ratio was observed for the Inuit (B=-0.002, p=0.044). In conclusion, there was a negative trend between Y:X ratio and PFOS in the Inuit, while there was no association between PFOA and the Y:X ratio in adult men.

• Author: Linus Kvist; Yvonne Giwercman; Bo A Jönsson; Christian Lindh; Jens-Peter Bonde; Gunnar Toft; Pawel Strucinski; Henning S Pedersen; Valentyna Zvyezday; Aleksander Giwercman
• Department/s: Molecular genetic reproductive medicine, Malmö; Reproductive medicine, Malmö; Division of Occupational and Environmental Medicine, Lund University
• Publishing year: 2012-10-05
• Language: English
• Publication/Series: Reproductive Toxicology
• Full text: - 461 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/23044208?dopt=Abstract; http://dx.doi.org/10.1016/j.reprotox.2012.09.007
• Document type: Journal article
• Publisher: Elsevier
• Topic: Obstetrics, Gynecology and Reproductive Medicine
• Status: Published
• Research group: Molecular genetic reproductive medicine, Malmö; Reproductive medicine, Malmö
• ISBN/ISSN/Other: ISSN: 1873-1708