Inhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic mice.

Summary, in English

Diabetic patients have a much more widespread and aggressive form of atherosclerosis and therefore, higher risk for myocardial infarction, peripheral vascular disease and stroke, but the molecular mechanisms leading to accelerated damage are still unclear. Recently, we showed that hyperglycemia activates the transcription factor NFAT in the arterial wall, inducing the expression of the pro-atherosclerotic protein osteopontin. Here we investigate whether NFAT activation may be a link between diabetes and atherogenesis.

• Author: Anna Zetterqvist; Lisa Berglund; Fabiana Blanco; Eliana Garcia Vaz; Maria Wigren; Pontus Dunér; Anna-Maria Dutius Andersson; Fong To; Peter Spégel; Jan Nilsson; Eva Bengtsson; Maria Gomez
• Department/s: Cardiovascular Research - Immunity and Atherosclerosis; Diabetic Complications; Diabetes - Molecular Metabolism; EXODIAB: Excellence of Diabetes Research in Sweden; EpiHealth: Epidemiology for Health
• Publishing year: 2013
• Language: English
• Publication/Series: PLoS ONE
• Volume: 8
• Issue: 6
• Full text: - 1 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/23755169?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0065020
• Document type: Journal article
• Publisher: Public Library of Science (PLoS)
• Topic: Cardiac and Cardiovascular Systems; Clinical Medicine; Endocrinology and Diabetes
• Status: Published
• Research group: Cardiovascular Research - Immunity and Atherosclerosis; Diabetic Complications; Diabetes - Molecular Metabolism
• ISBN/ISSN/Other: ISSN: 1932-6203