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Assignment of the human gene for beta-microseminoprotein (MSMB) to chromosome 10 and demonstration of related genes in other vertebrates

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Author

Summary, in English

The gene for beta-microseminoprotein MSMB has been studied by DNA hybridization and molecular cloning techniques. Comparative analysis of restriction endonuclease digests of the cloned gene and of leukocyte DNA strongly suggested that the gene is present in a single copy in the haploid human genome. By Southern blot analysis of DNA from somatic cell hybrids, the gene was assigned to chromosome 10. The coding nucleotides of the human gene are separated into four exons by relatively large introns. A related gene might be present in other mammals, birds, and amphibians as revealed by DNA hybridization under conditions of low stringency.

Publishing year

1991

Language

English

Pages

4-920

Publication/Series

Genomics

Volume

11

Issue

4

Document type

Journal article

Publisher

Academic Press

Topic

  • Medicinal Chemistry

Keywords

  • *Prostatic Secretory Proteins
  • Molecular Sequence Data
  • Humans
  • Dna
  • Molecular
  • Cloning
  • Pair 10
  • Human
  • *Chromosomes
  • Chromosome Mapping
  • Southern
  • Blotting
  • Animals
  • Base Sequence
  • Proteins/*genetics
  • Research Support
  • Non-U.S. Gov't
  • Restriction Mapping
  • Semen/*metabolism
  • Seminal Plasma Proteins
  • Vertebrates/genetics

Status

Published

Research group

  • Clinical Chemistry, Malmö

ISBN/ISSN/Other

  • ISSN: 1089-8646