Gene copy number changes in dermatofibrosarcoma protuberans - a fine-resolution study using array comparative genomic hybridization

Summary, in English

Dermatofibrosarcoma protuberans (DFSP) is a rare, slow-growing, low-grade dermal tumor. Cytogenetic and FISH studies have revealed that the chromosomal rearrangements characteristic of DFSP tumors involve both translocations and the formation of a supernumerary ring derived from chromosomes 17 and 22. The t(17;22) (q22;q13.1) translocation generates a gene fusion between COL1A1 and PDGFB, which serves as a diagnostic marker of DFSP. In the present study we performed array-CGH (aCGH) analysis on ten DFSP tumors. The COL1A1 region at 17q was gained in 71% (5/7) of the samples and the PDGFB region at 22q was gained in 43% (3/7) of the individual samples. In addition to the 17q and 22q gains, altogether 17 minimal common regions of gain and one region of loss were detected.

• Author: S. Kaur; H. Vauhkonen; T. Boehling; Fredrik Mertens; Nils Mandahl; S. Knuutila
• Department/s: Division of Clinical Genetics
• Publishing year: 2006
• Language: English
• Pages: 283-288
• Publication/Series: Cytogenetic and Genome Research
• Volume: 115
• Issue: 3-4
• Links: http://dx.doi.org/10.1159/000095925
• Document type: Journal article
• Publisher: Karger
• Topic: Medical Genetics
• Status: Published
• ISBN/ISSN/Other: ISSN: 1424-859X