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Oxidative activation of the propolis hapten isoprenyl caffeate

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Author

Summary, in English

The reactions of isoprenyl caffeate, the strongest allergen known to be present in propolis, with plausible functional groups of proteins were studied. The thiols glutathione and cysteine, which add to isoprenyl caffeate after having been oxidised to the corresponding quinone, served as model substances. The structure of the thiol adducts was determined by spectroscopic methods, addition being found to occur at C-2. The results support the hypothesis that the catecholic propolis hapten is a pro-hapten that forms a complete antigen after oxidation to caffeate quinone and addition to nucleophilic groups of proteins.

Publishing year

1995

Language

English

Pages

34-36

Publication/Series

Acta Dermato-Venereologica

Volume

75

Issue

1

Document type

Journal article

Publisher

Medical Journals Limited

Topic

  • Dermatology and Venereal Diseases

Status

Published

ISBN/ISSN/Other

  • ISSN: 1651-2057