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Nucleolar proteins with altered expression in leukemic cell lines.

På svenska

Author

  • Kaisa J Teittinen
  • Pauliina Kärkkäinen
  • Johanna Salonen
  • Gunilla Rönnholm
  • Hanna Korkeamäki
  • Mauno Vihinen
  • Nisse Kalkkinen
  • Olli Lohi

Summary, in English

The function of the nucleolus is intimately connected to cell proliferation, division and growth. Many cancer cells have enlarged nucleoli, and several nucleolar proteins have been linked to tumorigenesis. In order to find proteins whose expression is altered in the nucleoli of leukemic cells, we carried out two-dimensional difference gel electrophoresis (2-D DIGE) analyses. Prohibitin (PHB) and TAR-DNA-binding protein-43 (TDP-43) were strongly expressed in the nucleoli of the pre-B-ALL cell line MHH-CALL3. Our results demonstrate that leukemic cells have differences in their nucleolar protein composition, and suggest that it may be possible to exploit these differences in identification of leukemia subtypes.

Publishing year

2012

Language

English

Pages

232-236

Publication/Series

Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis

Volume

36

Issue

2

Document type

Journal article

Publisher

Elsevier

Topic

  • Cancer and Oncology

Keywords

  • Repressor Proteins: metabolism
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma: metabolism
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma: diagnosis
  • Nuclear Proteins: metabolism
  • Cell Nucleolus: metabolism
  • DNA-Binding Proteins: metabolism
  • Tumor Markers
  • Biological: metabolism

Status

Published

ISBN/ISSN/Other

  • ISSN: 1873-5835