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Insulin-like growth factor-1 in relation to adult weight and birth weight in healthy nulliparous women

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Author

Summary, in English

OBJECTIVE: To study the relationships between plasma insulin-like growth factor-1 (IGF-1) concentrations and birth weight, current weight and other constitutional factors among healthy, nulliparous women aged 19-25 years.

DESIGN AND METHODS: Forty healthy female university students aged 19-25 years volunteered for this study. They had never been pregnant and were not using oral contraceptives (OCs). Blood samples were drawn both in the follicular and luteal cycle phases (08:00-10:00 h) and weight, height, and waist-hip ratio were measured at the same time by one person (H.J). Information regarding age, birth weight, OC use, etc. was obtained from a questionnaire filled out by the women. Plasma IGF-1 concentrations were analyzed by radio immunoassay.

RESULTS: In a multivariate model including birth weight, current weight and age, IGF-1 was significantly inversely associated with birth weight in both cycle phases, while current weight was positively associated with IGF-1 in both cycle phases although only significantly so in the follicular phase. IGF-1 concentrations in both cycle phases showed a non-significant decrease with age.

CONCLUSION: In this group of 19-25-year-old healthy nulliparous women IGF-1 displayed a significant inverse association with birth weight in both cycle phases given that the current weight was adjusted for, while current weight was positively related to IGF-1 concentrations.

Publishing year

1998-07

Language

English

Pages

8-11

Publication/Series

International Journal of Gynecology & Obstetrics

Volume

62

Issue

1

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Cancer and Oncology

Keywords

  • Adult
  • Birth Weight
  • Body Weight
  • Female
  • Follicular Phase
  • Humans
  • Insulin-Like Growth Factor I
  • Luteal Phase
  • Multivariate Analysis

Status

Published

ISBN/ISSN/Other

  • ISSN: 1879-3479