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KinMutBase, a database of human disease-causing protein kinase mutations

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Author

Summary, in English

KinMutBase (http://www.uta.fi/imt/bioinfo/KinMutBase/) is a registry of mutations in human protein kinases related to-disorders. Kinases are essential cellular signaling molecules, in which mutations can lead to diseases, including immunodeficiencies, cancers and endocrine disorders, The first release of KinMutBase contained information for protein tyrosine kinases. The current release includes also serine/threonine protein kinases, as well as an update of the tyrosine kinases, There are 251 entries altogether, representing 337 families and 621 patients. Mutations appear both in conserved hallmark residues of the kinases as well as in non-homologous sites. The KinMutBase WWW pages provide plenty of information, namely mutation statistics land display, clickable sequences with mutations and changes to restriction enzyme patterns.

Publishing year

2000

Language

English

Pages

369-371

Publication/Series

Nucleic Acids Research

Volume

28

Issue

1

Document type

Journal article

Publisher

Oxford University Press

Topic

  • Medical Genetics

Status

Published

ISBN/ISSN/Other

  • ISSN: 1362-4962