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Oligosaccharides from faeces of a blood-group B, breast-fed infant

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Author

  • Hemant Sabharwal
  • Bo Nilsson
  • Alan Chester
  • Frank Lindh
  • Gunnar Grönberg
  • Sture Sjöblad
  • Arne Lundblad

Summary, in English

Eight oligosaccharides have been isolated from faeces of a blood group B, secretor, breast-fed infant and characterized by sugar and methylation analysis, f.a.b. mass spectrometry and 1H-n.m.r. spectroscopy. One of these oligosaccharides has not previously been reported and is a tri-L-fucosyl derivative of lacto-N-hexaose. The other compounds were identical to oligosaccharides found in human milk. Several of the reported compounds require the secretor dependent 2'-fucosyltransferase for their biosynthesis. Since the mother of this child was an O(H) non-secretor, an intestinal biosynthesis of at least some of these compounds is strongly indicated. No blood group B active oligosaccharides were detected which is in sharp contrast to the oligosaccharide excretion in faeces from a blood group A infant [Sabharwal et al., Mol. Immunol., 21 (1984) 1105-1112] in which all the major oligosaccharides isolated were blood group A active.

Publishing year

1988

Language

English

Pages

145-154

Publication/Series

Carbohydrate Research

Volume

178

Issue

1

Document type

Journal article

Publisher

Elsevier

Topic

  • Pediatrics
  • Hematology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1873-426X