Myeloid-related protein 14 promote inflammation and injury in meningitis.

Summary, in English

Neutrophilic inflammation often persists over days despite efficient antibiotic treatment and contributes to brain damage in bacterial meningitis. We proposed here that MRP14, an abundant cytosolic protein in myeloid cells, acts as an endogenous danger signal, driving inflammation and aggravating tissue injury.

• Author: Christina Wache; Matthias Klein; Christian Ostergaard; Barbara Angele; Hans Häcker; Hans-Walter Pfister; Monika Pruenster; Markus Sperandio; Tomas Leanderson; Johannes Roth; Thomas Vogl; Uwe Koedel
• Department/s: Immunology
• Publishing year: 2015
• Language: English
• Pages: 247-257
• Publication/Series: Journal of Infectious Diseases
• Volume: 212
• Issue: 2
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25605866?dopt=Abstract; http://dx.doi.org/10.1093/infdis/jiv028
• Document type: Journal article
• Publisher: Oxford University Press
• Topic: Infectious Medicine
• Status: Published
• Research group: Immunology
• ISBN/ISSN/Other: ISSN: 1537-6613