The DEK oncoprotein binds to highly and ubiquitously expressed genes with a dual role in their transcriptional regulation.

Summary, in English

The DEK gene is highly expressed in a wide range of cancer cells, and a recurrent translocation partner in acute myeloid leukemia. While DEK has been identified as one of the most abundant proteins in human chromatin, its function and binding properties are not fully understood.

• Author: Carl Sandén; Linnea Järvstråt; Andreas Lennartsson; Per Ludvik Brattaas; Björn Nilsson; Urban Gullberg
• Department/s: Transcriptional mechanisms for the Wilms’ tumor gene 1 (WT1) oncoprotein; Division of Hematology and Transfusion Medicine; Molecular Neurogenetics; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publishing year: 2014
• Language: English
• Publication/Series: Molecular Cancer
• Volume: 13
• Full text: - 866 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25216995?dopt=Abstract; http://dx.doi.org/10.1186/1476-4598-13-215
• Document type: Journal article
• Publisher: BioMed Central (BMC)
• Topic: Cancer and Oncology
• Status: Published
• Research group: Transcriptional mechanisms for the Wilms’ tumor gene 1 (WT1) oncoprotein; Molecular Neurogenetics
• ISBN/ISSN/Other: ISSN: 1476-4598