Once-weekly oral medication with alendronate does not prevent migration of knee prostheses
Author
Summary, in English
Background and purpose Early migration of joint replacements is an effect of poor fixation and can predict late loosening. By reducing the bone resorption after implantation of a joint replacement, it should be possible to enhance the initial fixation of the implant. We studied the effect of once-weekly treatment with alendronate after knee replacement. Patients and methods We recruited 60 patients (60 knees) with gonarthrosis who were scheduled for a total knee replacement. They were operated on with identical implants and uncemented fixation. 30 patients were treated with a bisphosphonate (alendronate) and 30 patients underwent placebo treatment. The treatment started postoperatively and continued on a weekly basis for 6 months. The fixation of the implants was measured with repeated radiostereometry for 2 years. Results There was no difference in migration of implants between the two groups. Conclusion With uncemented fixation of knee implants, no benefit of once-weekly treatment with alendronate, starting postoperatively, could be seen during a 2-year follow-up period.
Department/s
Publishing year
2009
Language
English
Pages
41-45
Publication/Series
Acta Orthopaedica
Volume
80
Issue
1
Links
Document type
Journal article
Publisher
Taylor & Francis
Topic
- Orthopedics
Keywords
- Osteoarthritis
- Knee: surgery
- Bone Resorption: radiography
- Bone Remodeling: drug effects
- Bone Density Conservation Agents: administration & dosage
- Bone Density: drug effects
- Alendronate: administration & dosage
- Knee: adverse effects
- Replacement
- Arthroplasty
Status
Published
ISBN/ISSN/Other
- ISSN: 1745-3682