Cytoskeletal and contractile proteins in detrusor smooth muscle from bladders with outlet obstruction--a comparative study in rat and man
Author
Summary, in English
Detrusor biopsies were obtained from patients with urinary outlet obstruction due to prostatic enlargement and from age-matched control patients. The relative amounts of actin and myosin and their isoforms, as well as desmin and filamin were determined and compared with corresponding results from bladders from control rats and rats with 10 days of experimental outlet obstruction of the urinary bladder. In the human control detrusor the actin/myosin ratio was similar to that in the control rat. The isoform distribution of the myosin heavy chains differed between man and rat. In the biopsies from the patients with outlet obstruction and in the obstructed rat bladders the actin/myosin ratio was increased. A change in the myosin heavy chain distribution in the obstructed bladders was observed for both species. The filamin/actin ratio increased significantly in the obstructed rat bladders and tended to increase in the obstructed human bladders. Desmin was the dominating intermediate filament protein. The desmin/actin ratio increased in obstructed bladders in man and in rat.
Publishing year
1991
Language
English
Pages
261-267
Publication/Series
Scandinavian Journal of Urology and Nephrology
Volume
25
Issue
4
Document type
Journal article
Publisher
Taylor & Francis
Topic
- Medicinal Chemistry
- Physiology
- Pharmacology and Toxicology
- Urology and Nephrology
Keywords
- myosin
- actin
- desmin
- filamin
- urinary bladder
- detrusor
- smooth muscle
- human
Status
Published
Research group
- Vascular Physiology
- Urology
ISBN/ISSN/Other
- ISSN: 0036-5599