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Human oral, gut, and plaque microbiota in patients with atherosclerosis

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Author

  • O. Koren
  • A. Spor
  • J. Felin
  • Frida Fåk
  • J. Stombaugh
  • V. Tremaroli
  • C. J. Behre
  • R. Knight
  • B. Fagerberg
  • R. E. Ley
  • F. Backhed
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Summary, in English

Periodontal disease has been associated with atherosclerosis, suggesting that bacteria from the oral cavity may contribute to the development of atherosclerosis and cardiovascular disease. Furthermore, the gut microbiota may affect obesity, which is associated with atherosclerosis. Using qPCR, we show that bacterial DNA was present in the atherosclerotic plaque and that the amount of DNA correlated with the amount of leukocytes in the atherosclerotic plaque. To investigate the microbial composition of atherosclerotic plaques and test the hypothesis that the oral or gut microbiota may contribute to atherosclerosis in humans, we used 454 pyrosequencing of 16S rRNA genes to survey the bacterial diversity of atherosclerotic plaque, oral, and gut samples of 15 patients with atherosclerosis, and oral and gut samples of healthy controls. We identified Chryseomonas in all atherosclerotic plaque samples, and Veillonella and Streptococcus in the majority. Interestingly, the combined abundances of Veillonella and Streptococcus in atherosclerotic plaques correlated with their abundance in the oral cavity. Moreover, several additional bacterial phylotypes were common to the atherosclerotic plaque and oral or gut samples within the same individual. Interestingly, several bacterial taxa in the oral cavity and the gut correlated with plasma cholesterol levels. Taken together, our findings suggest that bacteria from the oral cavity, and perhaps even the gut, may correlate with disease markers of atherosclerosis.

Publishing year

2011

Language

English

Pages

8-4592

Publication/Series

Proceedings of the National Academy of Sciences

Volume

108

Issue

Suppl. 1

Document type

Journal article

Publisher

National Academy of Sciences

Topic

  • Medical and Health Sciences

Keywords

  • Plaque
  • Phylogeny
  • Mouth/*microbiology
  • Molecular Sequence Data
  • Metagenome/*genetics
  • Male
  • Humans
  • Gastrointestinal Tract/*microbiology
  • Female
  • Cluster Analysis
  • Base Sequence
  • Bacteria/*genetics
  • Aged
  • Atherosclerosis/*microbiology
  • Atherosclerotic/*microbiology
  • Polymerase Chain Reaction
  • RNA
  • Ribosomal
  • 16S/genetics
  • Sequence Analysis
  • DNA
  • Species Specificity
  • Sweden

Status

Published

ISBN/ISSN/Other

  • ISSN: 1091-6490