Persistent organic pollutants have dose and CAG repeat length dependent effects on androgen receptor activity in vitro.

Summary, in English

Recently, the effect of exposure to persistent organic pollutants (POPs) on sperm concentration was only seen in men with a short androgen receptor (AR) gene CAG repeat. In order to investigate whether these effects could be observed also in vitro, we tested the impact of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (4,4'-DDE) on 5α-dihydrotestosterone activated ARs containing 16, 22 and 28 CAG repeats, respectively. Single exposure to 4,4'-DDE had the most pronounced effect on the AR activity containing 16 CAG repeats, whereas 28 CAG was the most sensitive variant when a mixture of the two compounds was added. Thus, our in vitro results have confirmed the in vivo data indicating a CAG repeat length dependent effect of endocrine disrupters on the AR activity.

• Author: Christel Björk; Hannah Nenonen; Aleksander Giwercman; Ake Bergman; Lars Rylander; Yvonne Giwercman
• Department/s: Reproductive medicine, Malmö; Molecular genetic reproductive medicine, Malmö; Division of Occupational and Environmental Medicine, Lund University
• Publishing year: 2011
• Language: English
• Pages: 293-297
• Publication/Series: Reproductive Toxicology
• Volume: 32
• Issue: 3
• Full text: - 223 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/21729750?dopt=Abstract; http://dx.doi.org/10.1016/j.reprotox.2011.06.075
• Document type: Journal article
• Publisher: Elsevier
• Topic: Obstetrics, Gynecology and Reproductive Medicine
• Status: Published
• Research group: Reproductive medicine, Malmö; Molecular genetic reproductive medicine, Malmö
• ISBN/ISSN/Other: ISSN: 1873-1708