Differences in Origin of Reactive Microglia in Bone Marrow Chimeric Mouse and Rat After Transient Global Ischemia.

Summary, in English

Current understanding of microglial involvement in disease is influenced by the observation that recruited bone marrow (BM)-derived cells contribute to reactive microgliosis in BM-chimeric mice. In contrast, a similar phenomenon has not been reported for BM-chimeric rats. We investigated the recruitment and microglial transformation of BM-derived cells in radiation BM-chimeric mice and rats after transientglobal cerebral ischemia, which elicits a characteristic microglialreaction. Both species displayed microglial hyperplasia and rod cell transformation in the hippocampal CA1 region. In mice, a subpopulation of lesion-reactive microglia originated from transformed BM-derived cells. By contrast, no recruitment or microglial transformation of BM-derived cells was observed in BM-chimeric rats. These results suggest that reactive microglia in rats originate from resident microglia, whereas they have a mixed BM-derived and resident origin in mice, depending on the severity of ischemic tissue damage.

• Author: Kate L Lambertsen; Tomas Deierborg; Rikke Gregersen; Bettina H Clausen; Martin Wirenfeldt; Helle H Nielsen; Ishar Dalmau; Nils H Diemer; Frederik Dagnaes-Hansen; Flemming F Johansen; Armand Keating; Bente Finsen
• Department/s: Department of Experimental Medical Science; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publishing year: 2011
• Language: English
• Pages: 481-494
• Publication/Series: Journal of Neuropathology and Experimental Neurology
• Volume: 70
• Issue: 6
• Links: http://www.ncbi.nlm.nih.gov/pubmed/21572335?dopt=Abstract; http://dx.doi.org/10.1097/NEN.0b013e31821db3aa
• Document type: Journal article
• Publisher: American Association of Neuropathologists
• Topic: Neurology
• Status: Published
• ISBN/ISSN/Other: ISSN: 1554-6578