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The mechanism of protein kinase C regulation

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Author

Summary, in English

Protein kinase C (PKC) is a family of serine/threonine protein kinases that plays a central role in transducing extracellular signals into a variety of intracellular responses ranging from cell proliferation to apoptosis. Nine PKC genes have been identified in the human genome, which encode 10 proteins. Each member of this protein kinase family displays distinct biochemical characteristics and is enriched in different cellular and subcellular locations. Activation of PKC has been implicated in the regulation of cell growth and differentiation. This review summarizes works of the past years in the field of PKC biochemistry that covers regulation and activation mechanism of different PKC isoforms.

Publishing year

2011

Language

English

Pages

328-336

Publication/Series

Frontiers in Biology

Volume

6

Issue

4

Document type

Journal article review

Publisher

Higher Education Press

Topic

  • Medicinal Chemistry

Keywords

  • PKC biochemistry PKC kinase PKC phosphatases PKC structure

Status

Published

ISBN/ISSN/Other

  • ISSN: 1674-7984