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Regulation of bone sialoprotein mRNA by steroid hormones.

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Author

Summary, in English

In this report we demonstrate an increase in the steady-state level of bone sialoprotein (BSP) mRNA in rat calvaria and a rat osteosarcoma cell line (ROS 17/2.8) after treatment with the synthetic glucocorticoid, dexamethasone. In contrast, 1.25-dihydroxyvitamin D3 reduced the amount of BSP mRNA in calvaria and inhibited the dexamethasone induction in ROS 17/2.8 cells. The increase in BSP mRNA is most likely due to an increase in the transcriptional rate. The stability of mRNA was unchanged after dexamethasone treatment with a half-life of approximately 5 h. Nuclear transcription experiments with nuclei isolated from ROS 17/2.8 cells showed an increased BSP mRNA synthesis in cells treated with dexamethasone.

Publishing year

1989

Language

English

Pages

3183-3186

Publication/Series

Journal of Cell Biology

Volume

109

Issue

6 Pt 1

Document type

Journal article

Publisher

Rockefeller University Press

Topic

  • Otorhinolaryngology

Keywords

  • Messenger: genetics
  • Messenger: drug effects
  • RNA
  • Genes: drug effects
  • Gene Expression Regulation: drug effects
  • Dexamethasone: pharmacology
  • Calcitriol: pharmacology
  • Bone and Bones: drug effects
  • Bone and Bones: metabolism
  • Sialoglycoproteins: genetics
  • Transcription
  • Genetic: drug effects

Status

Published

Research group

  • Åke Oldberg´s group

ISBN/ISSN/Other

  • ISSN: 0021-9525