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Synthesis of Substituted Oxazoles from N-Benzyl Propargyl Amines and Acid Chlorides

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Author

Summary, in English

The reaction between N-benzylpropargylamines and acid chlorides at elevated temperatures provides efficient, direct access to a variety of di- and tri-substituted oxazoles. The versatility of this reaction is explored and 21 examples are demonstrated. The usefulness of the methodology is showcased through the short and efficient formal syntheses of medicinally relevant drugs aleglitazar and romazarit.

Publishing year

2013

Language

English

Pages

4578-4585

Publication/Series

European Journal of Organic Chemistry

Volume

2013

Issue

21

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Chemical Sciences

Keywords

  • Synthetic methods
  • Cyclization
  • Heterocycles
  • Microwave chemistry

Status

Published

ISBN/ISSN/Other

  • ISSN: 1434-193X