Cord blood islet autoantibodies and seasonal association with the type 1 diabetes high-risk genotype.
Author
Summary, in English
Objective:Human leukocyte antigen DQ (HLA-DQ) genetic factors and islet autoantibodies are strongly associated with type 1 diabetes (T1D) and are currently used to predict T1D. This study examined whether islet autoantibodies in the cord blood of newborns to nondiabetic mothers were associated with the (T1D) high-risk genotype HLA-DQ2/8, gestational infections or both.Study Design:Cord blood samples were taken from 33 683 newborns and used for HLA typing and analyses of islet autoantibodies. Parents completed questionnaires when the child was 2 months of age.Result:The prevalence of newborn islet autoantibodies consistently varied with season over 4 years (P<0.0001); lowest in first quarter (1.2%) and highest in third (2.4%). Cord blood islet autoantibodies were associated with HLA-DQ2/8 in the second (OR, 2.30; P=0.02), third (OR, 2.12; P=0.008) and fourth quarters (OR, 2.49; P=0.007), but not in the first (OR, 1.13). Reported gastroenteritis was additionally associated with islet autoantibodies in the third quarter (OR, 1.80, P=0.04).Conclusion:An association between HLA and islet autoimmunity may depend on environmental exposure during pregnancy. Follow-up of mothers and children will determine risk of T1D.Journal of Perinatology (2008) 28, 211-217; doi:10.1038/sj.jp.7211912; published online 14 February 2008.
Department/s
Publishing year
2008
Language
English
Pages
211-217
Publication/Series
Journal of Perinatology
Volume
28
Issue
3
Links
Document type
Journal article
Publisher
Nature Publishing Group
Topic
- Environmental Health and Occupational Health
- Endocrinology and Diabetes
Status
Published
Research group
- Celiac Disease and Diabetes Unit
- Social Epidemiology
- Pediatric Autoimmunity
ISBN/ISSN/Other
- ISSN: 0743-8346