Structural studies of cysteine proteases and their inhibitors
Author
Summary, in English
Cysteine proteases (CPs) are responsible for many biochemical processes occurring in living organisms and they have been implicated in the development and progression of several diseases that involve abnormal protein turnover. The activity of CPs is regulated among others by their specific inhibitors: cystatins. The main aim of this review is to discuss the structure-activity relationships of cysteine proteases and cystatins, as well as of some synthetic inhibitors of cysteine proteases structurally based on the binding fragments of cystatins.
Department/s
Publishing year
2001
Language
English
Pages
1-20
Publication/Series
Acta Biochimica Polonica
Volume
48
Issue
1
Document type
Journal article review
Publisher
Panstwowe Wydawnictwo Naukowe
Topic
- Medicinal Chemistry
- Pharmacology and Toxicology
Keywords
- structure-activity relationship
- synthetic inhibitors
- cystatins
- cysteine proteases
Status
Published
ISBN/ISSN/Other
- ISSN: 0001-527X