Lipid metabolites as regulators of airway smooth muscle function
Author
Summary, in English
Compelling evidence identifies airway smooth muscle (ASM) not only as a target but also a cellular source for a diverse range of mediators underlying the processes of airway narrowing and airway hyperresponsiveness in diseases such as asthma. These include the growing family of plasma membrane phospholipid-derived polyunsaturated fatty acids broadly characterised by the prostaglandins, leukotrienes, lipoxins, isoprostanes and lysophospholipids. In this review, we describe the enzymatic and nonenzymatic biosynthetic pathways of these lipid mediators and how these are influenced by drug treatment, oxidative stress and airways disease. Additionally, we outline their cognate receptors, many of which are expressed by ASM. We describe potential deleterious and protective roles for these lipid mediators in airway inflammatory and remodelling processes by describing their effects on diverse functions of ASM in asthma that have the potential to contribute to asthma pathogenesis and symptoms. These functions include contractile tone development cytokine and extracellular matrix production, and cellular proliferation and migration. (C) 2008 Elsevier Ltd. All rights reserved.
Department/s
Publishing year
2009
Language
English
Pages
426-435
Publication/Series
Pulmonary Pharmacology & Therapeutics
Volume
22
Issue
5
Document type
Journal article
Publisher
Elsevier
Topic
- Cell and Molecular Biology
Keywords
- Proliferation
- Contraction
- Lysophospholipid
- Isoprostane
- Leukotriene
- Airway smooth muscle
- Prostanoid
- Migration
- Inflammation
Status
Published
Research group
- Lung Biology
ISBN/ISSN/Other
- ISSN: 1522-9629