Benzochromenes from the roots of Bourreria pulchra

Summary, in English

Two new benzochromenes, (6,6-dimethyl-2-methoxy-6H-benzo[c]chromen-9-yl)methanol (1), and 2-methoxy-6,6-dimethyl-6H-benzo[c]chromen-9-carbaldehyde (2), together with several already known metabolites, were isolated from the root extract of Bourreria pulchra (Boraginaceae). The structures of 1 and 2 were established on the basis of their spectroscopic data. Both were assayed for in vitro antiprotozoan activity, and especially 1 was found to possess significant activity against Leishmania mexicana and Trypanosoma cruzi parasites (IC50 4.6 mu g/mL and 7.5 mu g/mL, respectively). (C) 2009 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

• Author: Gilda J. Erosa-Rejon; Alejandro Yam-Puc; Manuel J. Chan-Bacab; Alberto Gimenez-Turbax; Efrain Salamanca; Luis M. Pena-Rodriguez; Olov Sterner
• Department/s: Centre for Analysis and Synthesis
• Publishing year: 2010
• Language: English
• Pages: 9-12
• Publication/Series: Phytochemistry Letters
• Volume: 3
• Issue: 1
• Links: http://dx.doi.org/10.1016/j.phytol.2009.10.002
• Document type: Journal article
• Publisher: Elsevier
• Topic: Organic Chemistry
• Keywords: Bourreria pulchra; Boraginaceae; Benzochromene; Antiprotozoal; Leishmania mexicana; Trypanosoma cruzi
• Status: Published
• ISBN/ISSN/Other: ISSN: 1874-3900