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Primary sequence differences between Chido and Rodgers variants of tryptic C4d of the human complement system

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Author

Summary, in English

Human tryptic C4d of the Chido and Rodgers variant was fragmented by cyanogen bromide and trypsin. The fragments were characterized by amino acid analysis and sequence determination. Polymorphism between the two genetic variants was detected in 5 positions. Four were closely located (residues 141, 142, 145, 146), where Leu, Ser, Ile, His occurred in the Chido variant and Pro, Cys, Leu, Asp in the Rodgers variant, respectively. In position 94 Gly was found in Chido and Asp in Rodgers. Alignment of the fragments was performed and it is concluded that tryptic C4d of both variants contains 346 residues.

Publishing year

1984

Language

English

Pages

8-254

Publication/Series

FEBS Letters

Volume

170

Issue

2

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Medicinal Chemistry

Keywords

  • Polymorphism
  • Peptide Fragments/*genetics
  • Humans
  • Cyanogen Bromide
  • *Complement C4b
  • Complement C4/*genetics
  • Comparative Study
  • Amino Acid Sequence
  • Blood Group Antigens/*genetics
  • Genetic
  • Research Support
  • Non-U.S. Gov't
  • Trypsin
  • *Variation (Genetics)

Status

Published

ISBN/ISSN/Other

  • ISSN: 1873-3468