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Telomerase in yeast

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Author

Summary, in English

The ribonucleoprotein enzyme telomerase synthesizes telomeric DNA by copying an internal RNA template sequence. The telomerase activities of the yeasts Saccharomyces castellii and Saccharomyces cerevisiae-with regular and irregular telomeric sequences, respectively-have now been identified and characterized. The S. cerevisiae activity required the telomerase RNA gene TLC1 but not the EST1 gene, both of which are required for normal telomere maintenance in vivo. This activity exhibited low processivity and produced no regularly repeated products. An inherently high stalling frequency of the S. cerevisiae telomerase may account for its in vitro properties and for the irregular telomeric sequences of this yeast.

Publishing year

1995

Language

English

Pages

396-400

Publication/Series

Science

Volume

269

Issue

5222

Document type

Journal article

Publisher

American Association for the Advancement of Science (AAAS)

Topic

  • Genetics

Status

Published

ISBN/ISSN/Other

  • ISSN: 1095-9203