The Notch and TGF-beta Signaling Pathways Contribute to the Aggressiveness of Clear Cell Renal Cell Carcinoma.

Summary, in English

Despite recent progress, therapy for metastatic clear cell renal cell carcinoma (CCRCC) is still inadequate. Dysregulated Notch signaling in CCRCC contributes to tumor growth, but the full spectrum of downstream processes regulated by Notch in this tumor form is unknown.

• Author: Jonas Sjölund; Anna-Karin Boström; David Lindgren; Sugata Manna; Aristidis Moustakas; Börje Ljungberg; Martin Johansson; Erik Fredlund; Håkan Axelson
• Department/s: Department of Translational Medicine; Breastcancer-genetics; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publishing year: 2011
• Language: English
• Publication/Series: PLoS ONE
• Volume: 6
• Issue: 8
• Full text: - 748 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/21826227?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0023057
• Document type: Journal article
• Publisher: Public Library of Science (PLoS)
• Topic: Cancer and Oncology
• Status: Published
• ISBN/ISSN/Other: ISSN: 1932-6203